What is the Myo-Reps Protocol?

The high-efficiency training method that delivers 3× the muscle growth stimulus in one-third the time

Reading time: 8 minutes

Key takeaway: 1 activation set + 3-5 mini-sets = the hypertrophy stimulus of 3 traditional sets

Created by: Borge Fagerli (Norwegian strength coach)

What Are Myo-Reps?

Myo-Reps is a training intensification technique developed by Borge Fagerli that dramatically increases training efficiency for hypertrophy (muscle growth). The protocol consists of:

  1. Activation Set: 1 set performed to near-failure (typically 10-20 reps at RIR 0-1)
  2. Brief Rest: 5 seconds to catch your breath (literally just count to 5)
  3. Mini-Sets: 3-5 additional mini-sets of 3-5 reps, each separated by 5-second rests

The entire sequence takes about the same time as ONE traditional set, yet provides the hypertrophy stimulus equivalent to 3 conventional sets.

The Science: How Myo-Reps Work

Myo-Reps leverage fundamental exercise physiology principles:

Motor Unit Recruitment

Your muscles contain motor units—bundles of muscle fibers controlled by a single nerve. Larger, more powerful motor units (Type II fibers) only activate when smaller ones can't produce enough force. They're recruited progressively as you near failure.1,2

Maintaining Recruitment with Mini-Sets

The 5-second rest periods keep all motor units active. The mini-sets continue loading those recruited motor units without accumulating excessive metabolic fatigue. You get:

  • Maximum motor unit recruitment (from activation set)
  • Sustained mechanical tension (from mini-sets)5
  • Minimal systemic fatigue (short total duration)
  • High time efficiency (3× stimulus in 1/3 the time)6

Step-by-Step: How to Perform Myo-Reps

  • Choose a weight where you reach failure (or very close) between 10-20 reps
  • Perform the set to RIR 0-1 (at or one rep from failure)
  • Control the tempo—don't rush through reps
  • Stop when you know you can't complete another rep with good form
  • Immediately after completing the activation set, rest for exactly 5 seconds
  • Take 3-5 deep breaths to partially clear metabolites
  • Stay in position—don't put the weight down if possible
  • This brief rest is critical: too short and you can't perform mini-sets, too long and motor units deactivate
  • Perform 3-5 reps (typically fewer than your activation set)
  • Stop when you feel you could only do 1-2 more reps
  • Rest another 5 seconds
  • Repeat the mini-set → 5-second rest cycle 2-3 more times
  • Expect rep counts to decrease slightly (5 → 4 → 4 → 3 is normal)
  • Maintain good form—if technique breaks down, stop
  • Total mini-sets: 3-5 depending on the exercise and your tolerance

Best Exercises for Myo-Reps

Myo-Reps work best with isolation exercises that don't produce excessive systemic fatigue:

  • Lateral raises (side delts)
  • Cable flies (chest)
  • Leg extensions (quads)
  • Leg curls (hamstrings)
  • Cable curls (biceps)
  • Cable pressdowns (triceps)
  • Calf raises
  • Abdominal crunches
  • Dumbbell rows (moderate systemic fatigue)
  • Romanian deadlifts (lower back fatigue)
  • Overhead press (requires stability)
  • Close-grip bench press (form can break down)
  • Squats (too much systemic fatigue)
  • Deadlifts (too much systemic fatigue)
  • Barbell bench press (safety concerns near failure)
  • Heavy barbell rows (form breakdown risk)

Benefits of Myo-Reps Training

Common Mistakes and How to Avoid Them

Sample Myo-Reps Workout

Here's an upper body accessory workout using Myo-Reps (15-20 minutes total):

Total workout time: ~18 minutes | Effective volume: 12 traditional sets worth of stimulus

Programming Myo-Reps into Your Training

How to integrate Myo-Reps effectively:

  • Compound exercises first: Start workouts with traditional straight sets for squats, deadlifts, presses
  • Myo-Reps for accessories: Use the protocol for isolation work at the end of sessions
  • 1-2 Myo-Reps blocks per muscle: One activation set sequence provides enough stimulus; don't overdo it. While local muscle fatigue is lower, you're still accumulating training stress.
  • Frequency: Can be used 2-3× per week for the same muscle group. While systemic fatigue is lower than traditional sets, the metabolic stress is still significant—monitor recovery.
  • Progression: Add reps to activation set or mini-sets before increasing weight. Aim to increase total reps across all mini-sets over time.

Try Myo-Reps with Minimum Viable Pump

MVP automatically incorporates Myo-Reps into your accessory work when appropriate. The app handles all the timing (5-second rest periods), rep tracking, and progression for you. Just focus on lifting.

Learn More About MVPRead FAQs

Scientific References

  1. Henneman, E., Somjen, G., & Carpenter, D. O. (1965). Functional significance of cell size in spinal motoneurons. Journal of Neurophysiology, 28(3), 560-580.
  2. Enoka, R. M., & Duchateau, J. (2008). Muscle fatigue: What, why and how it influences muscle function. The Journal of Physiology, 586(1), 11-23.
  3. Burd, N. A., et al. (2012). Muscle time under tension during resistance exercise stimulates differential muscle protein sub-fractional synthetic responses in men. The Journal of Physiology, 590(2), 351-362.
  4. Sundstrup, E., et al. (2012). Muscle activation strategies during strength training with heavy loading vs. repetitions to failure. Journal of Strength and Conditioning Research, 26(7), 1897-1903.
  5. Schoenfeld, B. J. (2010). The mechanisms of muscle hypertrophy and their application to resistance training. Journal of Strength and Conditioning Research, 24(10), 2857-2872.
  6. Fagerli, B. (2016). Myo-Reps: A high-efficiency training method for hypertrophy. Personal communication and coaching methodology.

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